Kōno is a Japanese family name, and may refer to:
- Hiromichi Kono (1905–1963), Japanese anthropologist and entomologist
- Takanori Kono
- Tarō Kōno, Japanese politician, son of Yōhei Kōno
- Tommy Kono, Japanese-American Olympic weightlifter
- Tomoyuki Kōno
- Yōhei Kōno, Speaker of the Japanese House of Representatives, father of Tarō Kōno
- Tetsuya Kono and Nahoko Kono, passengers on Comair Flight 191
- Masayuki Kono, Japanese professional wrestler and mixed martial artist