Knowle may refer to several places in the UK:
- Knowle, West Midlands, a village in the county of West Midlands, England
- Knowle, Bristol, a district and council ward of Bristol, England
- Knowle West, a neighbourhood in the south of Bristol, adjacent to Knowle.
- Knowle, Shropshire, a village in Shropshire, England
- Knowle, Devon a village near Braunton, Devon, England
- Knowle, a hamlet in the parish of Cullompton, Devon, England
- Knowle, Hampshire, a village in Hampshire, England, built on the site of Hampshire County Lunatic Asylum, renamed Knowle Mental Hospital in 1923 and Knowle Hospital in 1948.