KCR may refer to:
- Karachi Circular Railway, the proposed metro rail system of Karachi, Pakistan
- Kowloon-Canton Railway (British section), now part of MTR system in Hong Kong
- Kowloon-Canton Railway (Chinese section), now known as Guangshen Railway in Guangdong province, China
- Kowloon-Canton Railway Corporation, the corporation that operated Kowloon-Canton Railway network and property management
- KCR (SDSU), a student-run radio station at San Diego State University in San Diego, California, United States
- K. Chandrashekar Rao, founder of Telangana Rashtra Samithi, a political party in India
- Kansas City Royals, a Major League Baseball team
- KCR, a landmark crossroads in Dublin, Ireland
- KCR S.A., Contract Research Organization