Karnes is the name of several places:
In Norway:
- Karnes, Norway, near Lyngseidet
In the United States:
- Karnes City, Texas
- Karnes County, Texas
Karnes is also the surname of several people:
- Dave Karnes (born 1958), American Marine, rescuer of several survivors of the September 11, 2001 attacks
- David Karnes (born 1948), American politician
- Don Karnes, 1920s American football coach
- Henry Karnes (1812–1840), American soldier and Texas Ranger
- James Ernest Karnes (1889–1966), American World War I soldier
- Jay Karnes (born 1963), American actor
- Karen Karnes (born 1925), American potter
Karnes may also refer to:
- USS Karnes, 1944 American warship