Chemistry
Kaliotoxin is a 4-kDa polypeptide chain, containing 38 amino acids. The formula is C171H283N55O49S8. The sequence has a large homology with iberiotoxin from Buthus tumulus, charybdotoxin from Leiurus quinquestriatus and noxiustoxin from Centruroides noxius. An Important site of the toxin is the K27 side chain (a lysine at place 27 of the protein sequence), which enters the pore and protrudes into the selectivity filter of the channel. (Lange A et al., Korukottu J et al.)
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