Religion
- John Smith (bishop) (died 1479), bishop of Llandaff, 1476–1479
- John Smith (Platonist) (1618–1652), one of the founders of the Cambridge Platonists
- John Smith (Unitarian) (fl. 1648–1727), Unitarian writer
- John Smith (uncle of Joseph Smith) (1781–1854), Presiding Patriarch and member of the First Presidency of The Church of Jesus Christ of Latter-day Saints
- John Smith (clergyman) (1784–1868), early Restoration Movement leader
- John Smith (missionary) (1790–1824), English missionary in Demerara
- John Smith (nephew of Joseph Smith) (1832–1911), Presiding Patriarch of The Church of Jesus Christ of Latter-day Saints
- John Henry Smith (1848–1911), apostle in The Church of Jesus Christ of Latter-day Saints
- John Taylor Smith (1860–1938), Anglican Bishop of Sierra Leone
- John Smith (Archdeacon of Wiltshire) (1933–2000), Anglican priest
- John Mortimer Smith (born 1935), American bishop of the Roman Catholic Church
- John Smith (evangelist), Australian founder of God's Squad motorcycle club
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