Jeffrey may refer to:

  • Jeffrey (name), a common English name:
  • Jeffrey City, Wyoming
  • Jeffrey(s) Street, Sydney
  • Jeffrey (film), a 1995 movie by Paul Rudnick, based on Rudnick's play of the same name
  • Jeffrey's (sketch), a sketch on American TV show Saturday Night Live
  • Nurse Jeffrey, a spin-off miniseries from the American medical drama series House, MD