Jeffrey may refer to:
- Jeffrey (name), a common English name:
- Jeffrey City, Wyoming
- Jeffrey(s) Street, Sydney
- Jeffrey (film), a 1995 movie by Paul Rudnick, based on Rudnick's play of the same name
- Jeffrey's (sketch), a sketch on American TV show Saturday Night Live
- Nurse Jeffrey, a spin-off miniseries from the American medical drama series House, MD