Jayewardene may refer to:
- Mahela Jayawardene (born 1977), former captain of the Sri Lankan cricket team
- Prasanna Jayawardene (born 1979), a Sri Lankan cricketer
- Jayawardene Welathanthrige Hemantha Devapriya Boteju (born 1977), another Sri Lankan cricketer
- Junius Richard Jayewardene (1906–1996), Sri Lankan president from 1978 until 1989