Jaffe is a surname, and may refer to:
- Andrew Jaffe, cosmologist
- Arthur Jaffe, mathematical physicist
- Billy Jaffe (born 1969), color analyst for the New York Islanders on MSG Plus
- Charles Jaffe (circa 1879 – 12 July 1941), Belarusian-American chess master
- David Jaffe, video game designer and director
- David A. Jaffe, composer of contemporary classical and electronic/computer music
- Eliezer Jaffe, professor
- Jerome H. Jaffe, psychiatrist
- Marielle Jaffe (born 1989), an American model and actress
- Naomi Jaffe, activist
- Nicole Jaffe, American actress
- Norman Jaffe, American architect
- Sir Otto Jaffe (born 1846), prominent Jewish businessman, High Sheriff and Lord Mayor of Belfast
- Peter Jaffe (born 1913), British sailor and Olympic silver medalist
- Robert Jaffe, physicist and professor
- Robert Jaffe (stockbroker) (born 1944), associate of Bernard Madoff
- Rona Jaffe (born 1932), U.S. author
- Sam Jaffe (actor) (1891-1984), American film actor
- Sam Jaffe (producer) (1901-2000), American film producer later in England
- Sarah Jaffe (born 1986), American singer-songwriter
- Scott Jaffe (born 1969), American freestyle swimmer
- Stephen Jaffe, American composer