Receptor and Entry
The cellular receptor for JSRV is hyaluronidase 2 (Hyal2), a glycophosphatidylinol(GPI)-anchored protein belonging to the hyaluronidase family. Generally, oncogenic retroviruses cause transformation of host cells mostly by insertional activation of a host proto oncogene into an oncogene. But JSRV is different in this aspect since its envelope glycoprotein ("env") by itself is an oncogene and this single protein was shown to be necessary and sufficient to induce lung tumors in sheep (J Virol. 2006 Aug;80(16):8030-7. Unlike the majority of retroviruses, JSRV entry into the host cell is pH-dependent. Thus oncogenic JSRV has borrowed features of both pH-dependent and pH-independent viruses for entry which involves both the receptor binding and a low pH for fusion transformation of host cells.
Read more about this topic: Jaagsiekte Sheep Retrovirus
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