IWC may refer to:
- International WaterCentre, provides education and training, applied research and expert services in integrated water resource management
- International Wrestling Cartel, a professional Wrestling company
- Inch of water, (Inches Water Column) a measure of pressure
- Institute for Workers' Control, a defunct British Marxist organisation
- International Watch Company, a Swiss watch manufacturer
- International Whaling Commission
- International Wheat Council
- International Wheelset Congress, an annual international rail conference
- International Wireless Care, a department within AT&T Mobility of the USA to assist customers who roam internationally
- International Wolf Center, a wolf education facility based in Minnesota
- International Women's Club
- Irregular Webcomic!, a webcomic
- Institutional Wholesale Company, A wholesale food Distributor, Located in Algood Tennessee
- International Wine Challenge, an annual wine competition
- Iowa Wesleyan College, a liberal arts college located in Mount Pleasant, Iowa.
- Internet Wrestling Community, a nickname given to online postings or forums by fans of professional wrestling.