Isabelle is a French feminine given name. It may refer to :
- Isabella of France (disambiguation), a disambiguation page
- Isabelle of Luxembourg (1247–1298), a daughter of Henry V of Luxembourg and his wife Margaret of Bar
- Isabelle of Orléans (disambiguation), a disambiguation page
- Princess Isabelle (disambiguation), a disambiguation page
- Isabelle Abiera (born 1992), a Filipina actress and model
- Isabelle Adjani (born 1955), a French film actress and singer
- Isabelle Antena, a French singer
- Isabelle Arnould (born 1970), a retired Belgian female freestyle swimmer
- Isabelle Aubret (born 1938),a French singer
- Isabelle Autissier (born 1956), a French sailor, navigator, writer and broadcaster
- Isabelle Amyes (born 1950), an English actress
- Isabelle Blais (born 1975), a Canadian actress
- Isabelle Blanc (born 1975), a French snowboarder and Olympic champion
- Isabelle Boulay (born 1972), a francophone Canadian pop singer
- Isabelle Boulogne (born 1971), a French sprint canoer
- Isabelle Brasseur (born 1970), a Canadian figure skater
- Isabelle Breitman (born 1959), a French actress and director
- Isabelle Carbonell, a Belgio-Uruguayan documentary photographer and filmmaker
- Isabelle Caro, a French model suffering from severe anorexia nervosa
- Isabelle Carré (born 1971), a French actress
- Isabelle Champmoreau (born 1974), a New Caledonian politician
- Isabelle Charest (born 1971), a Canadian short track speed skater
- Isabelle Chartrand (born 1978), a Canadian ice hockey player
- Isabelle Cheng (born 1970), an intelligence agent
- Isabelle Collin Dufresne (aka Ultra Violet, born 1935), a French-American artist
- Isabelle Corey (born 1939), a French film actress
- Isabelle Coutant-Peyre (born 1952), a French lawyer
- Isabelle Daniels (born 1937), an American athlete, who mainly competed in the 100 metres
- Isabelle de Charrière (1740–1805), a Dutch-born writer of the Enlightenment
- Isabelle de Craon (1212-), a French noblewoman
- Isabelle Debré (born 1957), a member of the Senate of France
- Isabelle Delobel (born 1978), a French figure skater
- Isabelle Delorme (1900–1991), a Canadian composer, pianist and music educator
- Isabelle Deluce (born 1992), a Canadian actress
- Isabelle de Meulan (born c.1148-1220), a French noblewoman
- Isabelle Demongeot (born 1966), a former French professional tennis player
- Isabelle de Montolieu (1751–1832), a Swiss novelist and translator
- Isabelle Despres, a French slalom canoer
- Isabelle Devaluez (born 1966), a retired French discus thrower
- Isabelle Diks (born 1965), a Dutch GreenLeft politician
- Isabelle Dinoire (born 1967), the first person to undergo a partial face transplant
- Isabelle Duchesnay (born 1963), an ice dancer who competed for both Canada and France
- Isabelle Durant (born 1954), a Belgian politician, member of the Ecolo party
- Isabelle Eberhardt (1877–1904), a Swiss -Algerian explorer and writer
- Isabelle Ferron (born 1967), an actress in both film and stage
- Isabelle Fijalkowski (born 1972), a retired French basketball player
- Isabelle Flory, a French violinist
- Isabelle Fuhrman (born 1997), an American teen actress
- Isabelle Gatti de Gamond (1839–1905), an Italo-Belgian educationalist, feminist and politician
- Isabelle Goldenson (-2005)
- Isabelle Holland (1920–2002), an author of children and adult fiction books
- Isabelle Huppert (born 1953), a French actress
- Isabelle Keith (1898–1979), an American actress
- Isabelle LaMal (1886–1952), an American film actress
- Isabelle Lendl (born 1991), an American amateur golfer
- Isabelle Liberman (1918–1990), an American psychologist
- Isabelle Lucas (1927–1997), a Canadian-born British actress and singer
- Isabelle Mancini (born 1967), a French cross country skier
- Isabelle Mercier (born 1975), a Canadian professional poker player
- Isabelle Mir (born 1949), a French former Alpine skier
- Isabelle Morneau (born 1976), a defender on the Canada women's national soccer team
- Isabelle Mouthon-Michellys (born 1966), a French athlete
- Isabelle Nanty (born 1962), a French actress and film director
- Isabelle Nylander (born 1990), a Swedish figure skater
- Isabelle Pasco (born 1966), a French actress and model
- Isabelle Pasquet (born 1962), a member of the Senate of France
- Isabelle Pearson (born 1981), a Canadian judoka
- Isabelle Peretz, a Professor of Psychology at the University of Montreal
- Isabelle Pieman (born 1983), a Belgian figure skater
- Isabelle Poulenard (born 1961), a French soprano
- Isabelle Rampling (born 1985), a Canadian synchronized swimmer
- Isabelle Redford, an American artist, entrepreneur and philanthropist
- Isabelle Romée (1377–1458), the mother of Joan of Arc
- Isabelle Sadoyan (born 1928), a French actress
- Isabelle Sandy (1884–1975), a French poet and writer
- Isabelle Severino (born 1980), a French gymnast and actress
- Isabelle Simonis (born 1967), a Belgian politician from the Socialist Party
- Isabelle Stengers (born 1949), a Belgian philosopher and the daughter of the historian Jean Stengers
- Isabelle Stoehr (born 1979), a French professional squash player
- Isabelle Turcotte Baird (born 1970), a Canadian athlete
- Isabelle Urquhart (1865–1907), an American stage actress
- Isabelle Vasseur (born 1959), a member of the National Assembly of France
- Isabelle Vengerova (1877–1956), a Russian-born American pianist and music teacher
- Isabelle Wendling (born 1971), a French handball player
- Isabelle Wéry, a Belgian actress and writer
- Isabelle Westbury (born 1990), an English cricketer
- Isabelle White (1894–1972), a British diver
- fictional characters
- Isabelle (comics), a Belgian comic book series
- Isabelle of Cornwall, the mother of Tristan in Arthurian legend
- Isabelle Tyler, a fictional character on the USA Network science fiction television series The 4400
Isabelle is also the name of a mathematical theorem prover (proof assistant).