Genealogy
With the extinction of the progeny of her brothers, the title of Duke of Auvergne should have passed to her progeny. However with the confiscation of the possessions of Charles III, Duke of Bourbon, her niece's husband, the duchy of Auvergne was inherited by Louise of Savoy, King Francis's mother and hence was ultimately absorbed into the Crown lands. However, the title of Heir-General of the duchy of Auvergne passed through her daughter, Mary. Therefore the senior most claimant to the title as the heir General of Mary would be Infanta Alicia Of Spain
Read more about this topic: Isabella Of Bourbon