De Vos is a Dutch or Flemish surname that may refer to:
- Jan De Vos, 20th century mayor
- T.M. De Vos, 21st century poet and fiction writer
- Marten de Vos, 16th century painter
- Paul and Cornelis de Vos, 17th century painters (brothers)
- Simon de Vos, 17th century painter
- Jason deVos, modern sportsman
- The Michigan DeVoses:
- Richard DeVos, American businessman (co-founder of Amway)
- Dick DeVos, American businessmann and politician (candidate for Governor of Michigan); son of Richard
- Betsy DeVos, American Republican Party organizer; wife of Dick
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