IRM is a three-letter acronym that could refer to:
- Illinois Railway Museum
- Information Rights Management
- Information risk management
- Innate releasing mechanism
- Institute of Risk Management, a risk management professional education and training body
- Institute of Rural Management, a rural management learning and training body based in Pakistan
- Insurance Risk Managers
- Interference reflection microscopy, a microscopy method used to image adherent cells
- The Internal Revenue Manual of the IRS
- International Roaming MIN assigned by IFAST
- IRM (album), an album by Charlotte Gainsbourg
- Iron Mountain Incorporated, a data storage company based in Boston, Massachusetts
- Royal Meteorological Institute, the French name of the Belgian national weather service
- In Recent Memory