IRL may refer to:
- Republic of Ireland using ISO 3166-1 alpha-3 country code
- Industrial Research Limited, a New Zealand Crown Research Institute
- Indian River Lagoon
- Indy Racing League, the former name of IndyCar, a U.S. based sanctioning body of open-wheel racing
- In Real Life, a Canadian reality TV show
- Irlam railway station, England; National Rail station code IRL.
- Institute for Research on Learning, a research organization in Palo Alto, California, existing from 1986 to 2000
- Internet Resource Locator
- Ramon Llull Institute (Institut Ramon Llull), an organization for the promotion of Catalan language and culture
- Union of Pro Patria and Res Publica, an Estonian political party (in Estonian Isamaa ja Res Publica Liit)
- Internet slang meaning "In Real Life" commonly used when describing the reality of something
- Independent record label
- A slang abbreviation for Internet Radio Linking Project, IRLP