Irf3

IRF3

Identifiers Symbol IRF3 External IDs OMIM: 603734 MGI: 1859179 HomoloGene: 1208 GeneCards: IRF3 Gene

Gene Ontology
Molecular function	• DNA binding • sequence-specific DNA binding transcription factor activity • transcription cofactor activity • protein binding • identical protein binding • protein homodimerization activity • transcription regulatory region DNA binding
Cellular component	• nucleus • nucleoplasm • cytoplasm • cytosol • endosome membrane
Biological process	• negative regulation of transcription from RNA polymerase II promoter • MyD88-independent toll-like receptor signaling pathway • transcription from RNA polymerase II promoter • induction of apoptosis • response to DNA damage stimulus • Toll signaling pathway • virus-host interaction • cytokine-mediated signaling pathway • lipopolysaccharide-mediated signaling pathway • negative regulation of type I interferon production • positive regulation of type I interferon production • positive regulation of interferon-alpha production • positive regulation of interferon-beta production • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • TRIF-dependent toll-like receptor signaling pathway • MDA-5 signaling pathway • positive regulation of I-kappaB kinase/NF-kappaB cascade • response to exogenous dsRNA • innate immune response • type I interferon biosynthetic process • negative regulation of interferon-beta biosynthetic process • negative regulation of defense response to virus by host • positive regulation of cytokine secretion • defense response to virus • interferon-gamma-mediated signaling pathway • type I interferon-mediated signaling pathway • cellular response to dsRNA • macrophage apoptotic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3661 54131 Ensembl ENSG00000126456 ENSMUSG00000003184 UniProt Q14653 P70671 RefSeq (mRNA) NM_001197122.1 NM_016849.4 RefSeq (protein) NP_001184051.1 NP_058545.1 Location (UCSC) Chr 19:
50.16 – 50.17 Mb Chr 7:
45 – 45 Mb PubMed search

Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor.