Evolution
Examination of prokaryotic and eukaryotic forms of inorganic pyrophosphatase has shown that they differ significantly in both amino acid sequence, number of residues, and oligomeric organization. Despite differing structural components, recent work has suggested a large degree of evolutionary conservation of active site structure as well as reaction mechanism, based on kinetic data. Analysis of approximately one million genetic sequences taken from organisms in the Sargasso Sea identified a 57 residue sequence within the regions coding for inorganic pyrophosphatase that appears to be highly conserved; this region primarily consisted of the four early amino acid residues Gly, Ala, Val and Asp, suggesting an evolutionarily ancient origin for the protein.
Read more about this topic: Inorganic Pyrophosphatase
Famous quotes containing the word evolution:
“Like Freud, Jung believes that the human mind contains archaic remnants, residues of the long history and evolution of mankind. In the unconscious, primordial “universally human images” lie dormant. Those primordial images are the most ancient, universal and “deep” thoughts of mankind. Since they embody feelings as much as thought, they are properly “thought feelings.” Where Freud postulates a mass psyche, Jung postulates a collective psyche.”
—Patrick Mullahy (b. 1912)
“Analyze theory-building how we will, we all must start in the middle. Our conceptual firsts are middle-sized, middle-distanced objects, and our introduction to them and to everything comes midway in the cultural evolution of the race.”
—Willard Van Orman Quine (b. 1908)
“The evolution of humans can not only be seen as the grand total of their wars, it is also defined by the evolution of the human mind and the development of the human consciousness.”
—Friedrich Dürrenmatt (1921–1990)