An Open Future
The task of producing iPS cells continues to be challenging due to the five problems mentioned above. A key tradeoff to overcome is that between efficiency and genomic integration. Most methods that do not rely on the integration of transgenes are inefficient, while those that do rely on the integration of transgenes face the problems of incomplete reprogramming and tumor genesis, although a vast number of techniques and methods have been attempted. Another large set of strategies is to perform a proteomic characterization of iPS cells. The Wu group at Stanford University has made significant progress with this strategy. Further studies and new strategies should generate optimal solutions to the five main challenges. One approach might attempt to combine the positive attributes of these strategies into an ultimately effective technique for reprogramming cells to iPS cells.
Another approach is the use of iPS cells derived from patients to identify therapeutic drugs able to rescue a phenotype. For instance, iPS cell lines derived from patients affected by ectodermal dysplasia syndrome (EEC), in which the p63 gene is mutated, display abnormal epithelial commitment that could be partially rescued by a small compound
Read more about this topic: Induced Pluripotent Stem Cell
Famous quotes containing the words open and/or future:
“I think, for the rest of my life, I shall refrain from looking up things. It is the most ravenous time-snatcher I know. You pull one book from the shelf, which carries a hint or a reference that sends you posthaste to another book, and that to successive others. It is incredible, the number of books you hopefully open and disappointedly close, only to take down another with the same result.”
—Carolyn Wells (1862–1942)
“Perfect present has no existence in our consciousness. As I said years ago in Erewhon, it lives but upon the sufferance of past and future. We are like men standing on a narrow footbridge over a railway. We can watch the future hurrying like an express train towards us, and then hurrying into the past, but in the narrow strip of present we cannot see it. Strange that that which is the most essential to our consciousness should be exactly that of which we are least definitely conscious.”
—Samuel Butler (1835–1902)