Inhibitors
Norharmane, via inhibition of indoleamine 2,3-dioxygenase exerts neuroprotective properties by suppressing kynurenine neurotoxic metabolites such as quinolinic acid, 3-hydroxy-kynurenine and nitric oxide synthase. Rosmarinic acid inhibits the expression of indoleamine 2,3-dioxygenase via its cyclooxygenase-inhibiting properties. COX-2 inhibitors down-regulate indoleamine 2,3-dioxygenase, leading to a reduction in kynurenine levels as well as reducing proinflammatory cytokine activity.
| Indoleamine 2,3-dioxygenase |
|
| crystal structure of 4-phenylimidazole bound form of human indoleamine 2,3-dioxygenase |
| Identifiers |
| Symbol |
IDO |
| Pfam |
PF01231 |
| Pfam clan |
CL0380 |
| InterPro |
IPR000898 |
| PROSITE |
PDOC00684 |
| Available protein structures: |
| Pfam |
structures |
| PDB |
RCSB PDB; PDBe |
| PDBsum |
structure summary |
|
| Indoleamine 2,3-dioxygenase |
| Identifiers |
| EC number |
1.13.11.52 |
| CAS number |
9014-51-1 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
|
| Gene Ontology |
|
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI Protein |
search |
Read more about this topic: Indoleamine 2,3-dioxygenase
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