Indoleamine 2,3-dioxygenase

Indoleamine 2,3-dioxygenase

Identifiers Symbols IDO1; IDO; IDO-1; INDO External IDs OMIM: 147435 MGI: 96416 HomoloGene: 48082 ChEMBL: 4685 GeneCards: IDO1 Gene EC number 1.13.11.52

Gene Ontology
Molecular function	• tryptophan 2,3-dioxygenase activity • electron carrier activity • amino acid binding • oxygen binding • heme binding • indoleamine 2,3-dioxygenase activity • metal ion binding
Cellular component	• cytosol • smooth muscle contractile fiber • stereocilium bundle
Biological process	• cytokine production involved in inflammatory response • positive regulation of T cell tolerance induction • positive regulation of chronic inflammatory response • positive regulation of type 2 immune response • tryptophan catabolic process • female pregnancy • behavior • tryptophan catabolic process to kynurenine • response to lipopolysaccharide • negative regulation of interleukin-10 production • positive regulation of interleukin-12 production • multicellular organismal response to stress • kynurenic acid biosynthetic process • cellular nitrogen compound metabolic process • positive regulation of apoptotic process • small molecule metabolic process • negative regulation of activated T cell proliferation • negative regulation of T cell apoptotic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3620 15930 Ensembl ENSG00000131203 ENSMUSG00000031551 UniProt P14902 P28776 RefSeq (mRNA) NM_002164.5 NM_008324.1 RefSeq (protein) NP_002155.1 NP_032350.1 Location (UCSC) Chr 8:
39.76 – 39.79 Mb Chr 8:
24.58 – 24.6 Mb PubMed search

Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDO EC 1.13.11.52) is an enzyme that in humans is encoded by the IDO1 gene. This enzyme catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine.