The immunoglobulin heavy chain (IgH) is the large polypeptide subunit of an antibody (immunoglobulin).
A typical antibody is composed of two immunoglobulin (Ig) heavy chains and two Ig light chains. Several different types of heavy chain exist that define the class or isotype of an antibody. These heavy chain types vary between different animals. All heavy chains contain a series of immunoglobulin domains, usually with one variable domain (VH) that is important for binding antigen and several constant domains (CH1, CH2, etc.).
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Famous quotes containing the words heavy and/or chain:
“Now the hungry lion roars,
And the wolf behowls the moon;
Whilst the heavy ploughman snores,
All with weary task fordone.
Now the wasted brands do glow,
Whilst the screech-owl, screeching loud,
Puts the wretch that lies in woe
In remembrance of a shroud.
Now it is the time of night,
That the graves, all gaping wide,
Every one lets forth his sprite,
In the church-way paths to glide:”
—William Shakespeare (1564–1616)
“Nae living man I’ll love again,
Since that my lovely knight is slain.
Wi ae lock of his yellow hair
I’ll chain my heart for evermair.”
—Unknown. The Lament of the Border Widow (l. 25–28)