The immunoglobulin heavy chain (IgH) is the large polypeptide subunit of an antibody (immunoglobulin).
A typical antibody is composed of two immunoglobulin (Ig) heavy chains and two Ig light chains. Several different types of heavy chain exist that define the class or isotype of an antibody. These heavy chain types vary between different animals. All heavy chains contain a series of immunoglobulin domains, usually with one variable domain (VH) that is important for binding antigen and several constant domains (CH1, CH2, etc.).
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Famous quotes containing the words heavy and/or chain:
“There is nothing heavier than compassion. Not even one’s own pain weighs so heavy as the pain one feels with someone, for someone, a pain intensified by the imagination and prolonged by a hundred echoes.”
—Milan Kundera (b. 1929)
“The name of the town isn’t important. It’s the one that’s just twenty-eight minutes from the big city. Twenty-three if you catch the morning express. It’s on a river and it’s got houses and stores and churches. And a main street. Nothing fancy like Broadway or Market, just plain Broadway. Drug, dry good, shoes. Those horrible little chain stores that breed like rabbits.”
—Joseph L. Mankiewicz (1909–1993)