Route Description
Illinois 143 overlaps Illinois Route 157 and Illinois Route 159 in Edwardsville, and Illinois Route 160 and U.S. Route 40 in Highland. It has 4 lanes from IL 140 to just east of Illinois Route 255 around Southern Illinois University in Edwardsville, and briefly around Interstate 55 east of Edwardsville. The rest of the road is generally rural and has 2 lanes.
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