Route Description
Illinois 121 runs north from Greenup near Interstate 70. While traveling northwest, Illinois 121 passes through Toledo and has an interchange with Interstate 57 at Mattoon.
From there it runs northwest into the city limits of Decatur but largely goes around downtown using 22nd Street and Pershing Road. On the northwest side of Decatur, Illinois 121 intersects with the concurrent Interstate 72 and U.S. Route 51.
Illinois 121 continues further northwest into Lincoln, where it overlaps Illinois Route 10 through Lincoln as Keokuk Street and Woodlawn Road before terminating at Interstate 55 just south of Interstate 155. Illinois 10 continues west on the same road.
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