Il1a

IL1A

Identifiers Symbols IL1A; IL-1A; IL1; IL1-ALPHA; IL1F1 External IDs OMIM: 147760 MGI: 96542 HomoloGene: 480 GeneCards: IL1A Gene

Gene Ontology
Molecular function	• cytokine activity • interleukin-1 receptor binding • copper ion binding • protein binding
Cellular component	• extracellular region • extracellular space • cytosol • cell surface
Biological process	• fever generation • response to hypoxia • apoptotic process • anti-apoptosis • inflammatory response • immune response • cell proliferation • negative regulation of cell proliferation • response to ozone • response to organic nitrogen • response to gamma radiation • positive regulation vascular endothelial growth factor production • positive regulation of steroid biosynthetic process • response to organic cyclic compound • cytokine-mediated signaling pathway • keratinization • response to lipopolysaccharide • positive regulation of interleukin-6 production • response to L-ascorbic acid • cellular response to heat • wound healing • positive regulation of I-kappaB kinase/NF-kappaB cascade • positive regulation of interleukin-2 biosynthetic process • positive regulation of angiogenesis • positive regulation of mitosis • positive regulation of transcription from RNA polymerase II promoter • positive regulation of JNK cascade • response to copper ion • positive regulation of cytokine secretion • positive regulation of cell division • regulation of sensory perception of pain • positive regulation of ERK1 and ERK2 cascade
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3552 16175 Ensembl ENSG00000115008 ENSMUSG00000027399 UniProt P01583 P01582 RefSeq (mRNA) NM_000575.3 NM_010554.4 RefSeq (protein) NP_000566.3 NP_034684.2 Location (UCSC) Chr 2:
113.53 – 113.54 Mb Chr 2:
129.3 – 129.31 Mb PubMed search

Interleukin-1 alpha (IL-1α) is a protein of the interleukin-1 family that in humans is encoded by the IL1A gene. In general, Interleukin 1 is responsible for the production of inflammation, as well as the promotion of fever and sepsis. IL-1α inhibitors are being developed to interrupt those processes and treat diseases.