Ike may refer to:
- Dwight D. Eisenhower (1890–1969), a five-star general in the United States Army and the 34th President of the United States, popularly known as "Ike"
- USS Dwight D. Eisenhower (CVN-69), the second Nimitz-class supercarrier, also known as the Ike
- Ike: Countdown to D-Day, a 2004 American television film
- Interstate 290 (Illinois), a portion of which is officially named the Dwight D. Eisenhower Expressway, or "the Ike"
- I like Ike, a popular slogan around the 1950s
- Ike (TV miniseries), 1979 television miniseries about Dwight D. Eisenhower
- Ike Davis (born 1987), a first baseman for the New York Mets in Major League Baseball
- Ike Taylor (born 1980), a defensive back for the Pittsburgh Steelers in the NFL
- Ike Turner (1931–2007), an American musician, bandleader, talent scout, and record producer
- a shortened form of the name Isaac
In fiction:
- Alibi Ike, a series of short stories written by Ring Lardner
- Ike, the main character in the video games Fire Emblem: Path of Radiance and Fire Emblem: Radiant Dawn, and a playable fighter in Super Smash Bros. Brawl
- Ike Anwhistle, a character from A Series of Unfortunate Events
- Ike Broflovski, a recurring fictional character in the cartoon series South Park
- Ike, a nickname for the main probe (Isaac Newton) from the mockumentary Alien Planet
In weather:
- Tropical Storm Ike (disambiguation), six storms
- Hurricane Ike, the third-costliest hurricane to ever make landfall in the United States
- 1981's Typhoon Ike, a category 1 typhoon that formed in the South China Sea
- 1984's Typhoon Ike, the deadliest typhoon of the 1984 Pacific typhoon season