Ikbkg

IKBKG

Identifiers Symbols IKBKG; AMCBX1; FIP-3; FIP3; Fip3p; IKK-gamma; IP; IP1; IP2; IPD2; NEMO External IDs OMIM: 300248 MGI: 1338074 HomoloGene: 2698 ChEMBL: 4967 GeneCards: IKBKG Gene

Gene Ontology
Molecular function	• signal transducer activity • protein binding • protein domain specific binding • metal ion binding
Cellular component	• intracellular • nucleus • cytoplasm • cytosol • IkappaB kinase complex • cytoplasmic part
Biological process	• activation of MAPK activity • B cell homeostasis • toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • transcription, DNA-dependent • induction of apoptosis • inflammatory response • immune response • response to DNA damage stimulus • I-kappaB kinase/NF-kappaB cascade • activation of NF-kappaB-inducing kinase activity • JNK cascade • Toll signaling pathway • response to virus • virus-host interaction • positive regulation of type I interferon production • toll-like receptor 1 signaling pathway • toll-like receptor 2 signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • TRIF-dependent toll-like receptor signaling pathway • nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway • positive regulation of I-kappaB kinase/NF-kappaB cascade • innate immune response • T cell receptor signaling pathway • positive regulation of NF-kappaB transcription factor activity • stress-activated MAPK cascade • nucleotide-binding oligomerization domain containing signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 8517 16151 Ensembl ENSG00000073009 ENSMUSG00000004221 UniProt Q9Y6K9 O88522 RefSeq (mRNA) NM_001099856.2 NM_001136067.2 RefSeq (protein) NP_001093326.2 NP_001129539.1 Location (UCSC) Chr X:
153.77 – 153.8 Mb Chr X:
74.39 – 74.45 Mb PubMed search

NF-kappa-B essential modulator (NEMO) also known as inhibitor of nuclear factor kappa-B kinase subunit gamma (IKK-γ) is a protein that in humans is encoded by the IKBKG gene. NEMO is a subunit of the IκB kinase complex that activates NF-κB. The human gene for IKBKG is located on chromosome Xq28. Multiple transcript variants encoding different isoforms have been found for this gene.