Vishtaspa, Hellenized as Hystaspes (Ὑστάσπης), may refer to:
- Vishtaspa (fl. 10th century BCE or earlier, if actually historical), the first patron of Zoroaster
- Hystaspes (father of Darius I) (fl. 550 BCE), satrap of Bactria and possibly also of Fārs, and father of Darius the Great
- Hystaspes (son of Darius I) (fl. ca. 480 BCE), son of Darius the Great
- Hystaspes (son of Xerxes I) (fl. ca. 460 BCE), son of Xerxes I of Persia