Dynamic Nuclear Polarization
Compounds containing NMR-sensitive nuclei, such as 13C or 15N, can be hyperpolarized using Dynamic Nuclear Polarisation (DNP). DNP is typically performed at low temperature (≈1 K) and high magnetic field (≈3 T). The compound is subsequently thawed and dissolved to yield a room temperature solution containing hyperpolarized nuclei. This liquid can be used in in vivo metabolic imaging for oncology and other applications. The 13C polarization levels in solid compounds can reach up to ≈64% and the losses during dissolution and transfer of the sample for NMR measurements can be minimized to a few percent. Compounds containing NMR-sensitive nuclei can also be hyperpolarized using chemical reactions with para-hydrogen. This process is called Para-Hydrogen Induced Polarization (PHIP).
Read more about this topic: Hyperpolarization (physics)
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