Humfrey can refer to
- William Humfrey, goldsmith and Assay Master to Queen Elizabeth I of England.
- Humfrey Malins, British Conservative polititican.
- Humfry Payne (1902-1936), English archaeologist
- Various fictional characters in The family of Humfrey of Xanth
- Pelham Humfrey (1647-1674), English Restoration composer