Importance of Iron Regulation
Iron is an absolute requirement for most forms of life, including humans and most bacterial species, because plants and animals all use iron; hence, iron can be found in a wide variety of food sources.
Iron is essential to life because of its unusual flexibility to serve as both an electron donor and acceptor.
Iron can also be potentially toxic. Its ability to donate and accept electrons means that if iron is free within the cell, it can catalyze the conversion of hydrogen peroxide into free radicals. Free radicals can cause damage to a wide variety of cellular structures, and ultimately kill the cell. To prevent that kind of damage, all life forms that use iron bind the iron atoms to proteins. That allows the cells to use the benefits of iron, but also limit its ability to do harm.
The most important group of iron-binding proteins contain the heme molecules, all of which contain iron at their centers. Humans and most bacteria use variants of to carry out redox reactions and electron transport processes. These reactions and processes are required for oxidative phosphorylation. That process is the principal source of energy for human cells; without it, most types of cells would die.
The iron-sulfur proteins are another important group of iron-containing proteins. Some of these proteins are also essential parts of oxidative phosphorylation.
Humans also use iron in the hemoglobin of red blood cells, in order to transport oxygen from the lungs to the tissues and to transport carbon dioxide back to the lungs. Iron is also an essential component of myoglobin to store and diffuse oxygen in muscle cells.
The human body needs iron for oxygen transport. That oxygen is required for the production and survival of all cells in our bodies. Human bodies tightly regulate iron absorption and recycling. Iron is such an essential element of human life, in fact, that humans have no physiologic regulatory mechanism for excreting iron. Most humans prevent iron overload solely by regulating iron absorption. Those who cannot regulate absorption well enough get disorders of iron overload. In these diseases, the toxicity of iron starts overwhelming the body's ability to bind and store it.
Read more about this topic: Human Iron Metabolism
Famous quotes containing the words importance of, importance, iron and/or regulation:
“One’s condition on marijuana is always existential. One can feel the importance of each moment and how it is changing one. One feels one’s being, one becomes aware of the enormous apparatus of nothingness—the hum of a hi-fi set, the emptiness of a pointless interruption, one becomes aware of the war between each of us, how the nothingness in each of us seeks to attack the being of others, how our being in turn is attacked by the nothingness in others.”
—Norman Mailer (b. 1923)
“A man’s personal defects will commonly have with the rest of the world precisely that importance which they have to himself. If he makes light of them, so will other men.”
—Ralph Waldo Emerson (1803–1882)
“And thus Snow White became the prince’s bride.
The wicked queen was invited to the wedding feast
and when she arrived there were
red-hot iron shoes,
in the manner of red-hot roller skates,
clamped upon her feet.”
—Anne Sexton (1928–1974)
“Nothing can be more real, or concern us more, than our own sentiments of pleasure and uneasiness; and if these be favourable to virtue and unfavourable to vice, no more can be requisite to the regulation of our conduct and behavior.”
—David Hume (1711–1776)