Huggins refers to:
People with the surname Huggins:
- Bob Huggins (born 1953), American college basketball coach
- Charles Brenton Huggins (1901–1997), Canadian-born American physician, physiologist, and cancer researcher
- Charlie Huggins (born 1947), member of the Alaska Senate
- Godfrey Huggins, 1st Viscount Malvern (1883–1971), Rhodesian politician and physician
- Jeremy Brett (Whose actual name is Jeremy Huggins, but was not allowed to use his family name as his stage name by order of his father)
- John Huggins (1945–1969), American Black Panther party political activist
- Margaret Lindsay Huggins (1848–1915), British astronomer; pioneer in the field of spectroscopy
- Maurice Loyal Huggins (1897–1981), scientist and chemist
- Miller Huggins (1879–1929), American professional baseball player and manager
- Roy Huggins (1914–2002), American novelist, screenwriter, and television producer
- William Huggins (1820-84), English animal artist
- William Huggins (1824–1910), British astronomer
- Ben Huggins, singer in Texan rock band Galactic Cowboys
In fictional characters:
- Henry Huggins, a character in a series of juvenile fiction novels by Beverly Cleary
In places:
- Huggins, Missouri, USA
Other:
- Flory-Huggins solution theory, mathematical model of the thermodynamics of polymer solutions
- Huggins (lunar crater)