HPR may mean:
- Hydraulic Power Reversible pack or unit (as accumulator)
- Harvard Political Review
- Hawaii Public Radio
- Heartland Public Radio
- Heading, Pitch, Roll
- High Power Rocketry
- Holding Period Return
- Human Proteome Resource program
- Host plant resistance
- Home Page Reader an Aural Browser and Screen Reader from IBM
- HPR Foreign Trade Co. (Hobby & Toys Importer located Istanbul Turkey)
- HPR (gene)
- Homiletic and Pastoral Review
- Hacker Public Radio