Holness is the surname of several notable people, most prevalent in England and the Caribbean:
- Matthew Holness - English comedian
- Bob Holness - English actor and presenter
- Adele Holness - English electronic musician
- Winston "Niney The Observer" Holness - Jamaican record producer
- Nicole Holness - one of seven hosts of MTV Canada
- Ned Holness, boyhood assumed name of comedian Carlos Mencia