HLN may refer to:
- HLN (TV channel), a cable network formerly known as Headline News
- The IATA airport code for Helena Regional Airport
- The Horizon League Network—see Horizon League#Horizon League Network
- The shorthand notation of Phenolphthalein
- Het Laatste Nieuws ("The Latest News"), a Dutch language newspaper based in Brussels, Belgium
- Hlavní nádraží (disambiguation) (Czech for a main or central railway station)