HLF may refer to:
- HLF (gene), Hepatic Leukemia Factor - a human gene and the protein encoded by it
- ICAO code for Hapag-Lloyd Flug
- Heritage Lottery Fund, a United Kingdom grant-giving organisation
- Holy Land Foundation for Relief and Development, Islamic charity located in the USA
- Hyderabad Literary Festival, an annual literature festival held in Hyderabad, India
Read more about HLF: Other