HLA B7-DR15-DQ6 - Disease Associations

Disease Associations

HLA B7-DR15-DQ6 was found to have an association with postmenopausal osteoporosis in a Greek population.

DR2 (15 or 16) -DQ6.2 has been found to associate with (idiopathic) narcolepsy-cataplexy Hypocretin ligand deficiency in the brain and cerebrospinal fluid is also link to narcolepsy-cataplexy. DR15-DQ6 also shows an association with factors (including a genetic factor on chromosome 12p12) involved in familial multiple sclerosis DR15-DQ6 is strongly associated with the development of choroidal neovascular lesions in presumed ocular histoplasmosis syndrome.

The DR15-DQ6 haplotype may afford some greater protection against the progression of HIV. However, the haplotype is a risk factor in cervical cancer.

Read more about this topic:  HLA B7-DR15-DQ6

Famous quotes containing the words disease and/or associations:

    It is useless to check the vain dunce who has caught the mania of scribbling, whether prose or poetry, canzonets or criticisms,—let such a one go on till the disease exhausts itself. Opposition like water, thrown on burning oil, but increases the evil, because a person of weak judgment will seldom listen to reason, but become obstinate under reproof.
    Sarah Josepha Buell Hale 1788–1879, U.S. novelist, poet and women’s magazine editor. American Ladies Magazine, pp. 36-40 (December 1828)

    Hardly a man in the world has an opinion upon morals, politics or religion which he got otherwise than through his associations and sympathies. Broadly speaking, there are none but corn-pone opinions. And broadly speaking, Corn-Pone stands for Self- Approval. Self-approval is acquired mainly from the approval of other people. The result is Conformity.
    Mark Twain [Samuel Langhorne Clemens] (1835–1910)