HFE may refer to:
- hfe, the small signal Forward Current Gain of a bipolar junction transistor
- HFE (gene), a gene that encodes the Human hemochromatosis protein
- Herschend Family Entertainment Corporation, a privately owned themed-entertainment company
- Hidden Field Equations, a public key cryptosystem
- Human factors engineering, a discipline of design based on human capabilities
- Hydrofluoroether, a complex organic solvent
- Hefei Luogang International Airport, an airport in Hefei, Anhui Provience, in the People’s Republic of China