Benefit To Persons With Sickle Cell Disease
In persons with sickle cell disease, high levels of fetal hemoglobin as found in a newborn or as found abnormally in persons with hereditary persistence of fetal hemoglobin, the HbF causes the sickle cell disease to be less severe. In essence the HbF inhibits polymerization of HbS. A similar mechanism occurs with persons who have sickle cell trait. Approximately 40% of the hemoglobin is in the HbS form while the rest is in HbA form. The HBA form interferes with HbS polymerization.
Read more about this topic: Hereditary Persistence Of Fetal Hemoglobin
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