HDAC8

HDAC8

Identifiers Symbols HDAC8; CDLS5; HD8; HDACL1; MRXS6; RPD3; WTS External IDs OMIM: 300269 MGI: 1917565 HomoloGene: 41274 ChEMBL: 3192 GeneCards: HDAC8 Gene EC number 3.5.1.98

Gene Ontology
Molecular function	• histone deacetylase activity • transcription factor binding • NAD-dependent histone deacetylase activity (H3-K14 specific) • metal ion binding • NAD-dependent histone deacetylase activity (H3-K9 specific) • NAD-dependent histone deacetylase activity (H4-K16 specific) • NAD-dependent histone deacetylase activity (H3-K18 specific)
Cellular component	• histone deacetylase complex • nuclear chromosome • nucleus • cytoplasm • cohesin complex
Biological process	• negative regulation of transcription from RNA polymerase II promoter • chromatin assembly or disassembly • transcription, DNA-dependent • chromatin modification
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 55869 70315 Ensembl ENSG00000147099 ENSMUSG00000067567 UniProt Q9BY41 Q8VH37 RefSeq (mRNA) NM_001166418 NM_027382 RefSeq (protein) NP_001159890 NP_081658 Location (UCSC) Chr HG1438_PATCH:
71.55 – 71.79 Mb Chr X:
102.28 – 102.51 Mb PubMed search

Histone deacetylase 8 is an enzyme that in humans is encoded by the HDAC8 gene, and is biologically involved in skull morphogenesis and metabolic control of the ERR-alpha/PGC1-alpha transcriptional complex.

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter.