HDAC6

HDAC6

Identifiers Symbols HDAC6; HD6 External IDs OMIM: 300272 MGI: 1333752 HomoloGene: 31353 ChEMBL: 1865 GeneCards: HDAC6 Gene EC number 3.5.1.98

Gene Ontology
Molecular function	• actin binding • histone deacetylase activity • protein binding • beta-catenin binding • microtubule binding • zinc ion binding • enzyme binding • polyubiquitin binding • NAD-dependent histone deacetylase activity (H3-K14 specific) • histone deacetylase binding • tubulin deacetylase activity • alpha-tubulin binding • metal ion binding • NAD-dependent histone deacetylase activity (H3-K9 specific) • NAD-dependent histone deacetylase activity (H4-K16 specific) • tau protein binding • beta-tubulin binding • Hsp90 protein binding • dynein complex binding • NAD-dependent histone deacetylase activity (H3-K18 specific)
Cellular component	• histone deacetylase complex • nucleus • nucleolus • cytoplasm • cytosol • microtubule • microtubule associated complex • cytoplasmic microtubule • caveola • inclusion body • aggresome • dynein complex • cell leading edge • perinuclear region of cytoplasm
Biological process	• protein polyubiquitination • transcription, DNA-dependent • protein deacetylation • misfolded or incompletely synthesized protein catabolic process • intracellular protein transport • negative regulation of microtubule depolymerization • response to toxin • positive regulation of signal transduction • response to organic substance • regulation of receptor activity • positive regulation of epithelial cell migration • negative regulation of hydrogen peroxide metabolic process • positive regulation of receptor biosynthetic process • macroautophagy • histone deacetylation • lysosome localization • peptidyl-lysine deacetylation • cellular response to topologically incorrect protein • positive regulation of apoptotic process • ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway • protein complex disassembly • negative regulation of protein complex disassembly • negative regulation of proteolysis • negative regulation of transcription, DNA-dependent • negative regulation of oxidoreductase activity • response to misfolded protein • regulation of microtubule-based movement • regulation of androgen receptor signaling pathway • cellular response to hydrogen peroxide • aggresome assembly • polyubiquitinated misfolded protein transport • Hsp90 deacetylation • response to growth factor stimulus • cellular response to misfolded protein • positive regulation of chaperone-mediated protein complex assembly • tubulin deacetylation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 10013 15185 Ensembl ENSG00000094631 ENSMUSG00000031161 UniProt Q9UBN7 Q9Z2V5 RefSeq (mRNA) NM_006044 NM_001130416 RefSeq (protein) NP_006035 NP_001123888 Location (UCSC) Chr HG1436_HG1432_PATCH:
48.66 – 48.68 Mb Chr X:
7.93 – 7.95 Mb PubMed search

Histone deacetylase 6 is an enzyme that in humans is encoded by the HDAC6 gene.

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromatin structure and has affects transcription. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.