Hbb

HBB

Identifiers Symbols HBB; CD113t-C; beta-globin External IDs OMIM: 141900 MGI: 96022 HomoloGene: 68066 ChEMBL: 4331 GeneCards: HBB Gene

Gene Ontology
Molecular function	• peroxidase activity • oxygen transporter activity • iron ion binding • protein binding • oxygen binding • heme binding • hemoglobin binding • haptoglobin binding
Cellular component	• cytosol • hemoglobin complex • haptoglobin-hemoglobin complex
Biological process	• blood coagulation • regulation of blood pressure • positive regulation of cell death • oxygen transport • bicarbonate transport • nitric oxide transport • response to hydrogen peroxide • hydrogen peroxide catabolic process • small molecule metabolic process • positive regulation of nitric oxide biosynthetic process • regulation of blood vessel size • protein heterooligomerization • renal absorption
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 3043 15129 Ensembl ENSG00000244734 ENSMUSG00000052305 UniProt P68871 P02088 RefSeq (mRNA) NM_000518.4 NM_008220.4 RefSeq (protein) NP_000509.1 NP_032246.2 Location (UCSC) Chr 11:
5.25 – 5.25 Mb Chr 7:
103.81 – 103.81 Mb PubMed search

Beta globin (HBB, β-globinprotin), along with alpha globin (HBA), makes up the most common form of hemoglobin in adult humans. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains.