Harry Demopoulos - Works

Works

  • Flamm ES, Demopoulos HB, Seligman ML, Poser RG, Ransohoff J., Free radicals in cerebral ischemia, Stroke. 1978 Sep-Oct;9(5):445-7.
Generally acknowledged as the first experimental demonstration of a role for reactive oxygen species in stroke.
  • Demopoulos, H. B,, Flamm, E. S., Pietronegro, D. D., and Seligman, M. L., The free radical pathology and the microcirculation in the major central nervous system disorders, Acta Physiol. Scand. Suppl., 492, 91, 1980.
This paper first suggests that free radical pathogenesis in stroke may be at least partially mediated through damage to the microcirculation. The neuroprotective antistroke agents NXY-059, Tirilazad, Superoxide dismutase/Catalase, and uric acid all likely work at this level, rather than interneuronally.
  • Demopoulos, H., Flamm, E., Seligman, M. L., Poser, R., Pietronegro, D., and Ransohoff, J., Molecular pathology of lipids in CNS membranes, in Oxygen and Physiological Function, Volsis, F. F., Ed., Professional Information Library, Dallas, Tex., 1977, 491.
  • Demopoulos, H. B., Flamm, E., Seligman, M,, and Pietronigro, D. D., Oxygen free radicals in central nervous system ischaemia and trauma, in Pathology of Oxygen, Autor, A. P., Ed., Academic Press, New York, 1982, 127.
"Large doses of methohexital protect the microcirculation in regional cerebral ischaemia models". This is the first well-defined example of an antistroke neuroprotective agent working outside the blood–brain barrier. NXY-059, Superoxide dismutase, catalase, uric acid, and Tirilazad are others.
  • John McGinness, Proctor, P.H., Demopoulos, H.B., Hokansen, J.A. and Kirkpatrick, D. S. Amelioration of cis-platinum nephrotoxicity by orgotein (superoxide dismutase). Physiol. Chem. and Phys. 10: 267-277, 1978.
  • John McGinness, Proctor, P.H., Demopoulos, H.B., Hokansen, J.A. and Van, N.T. In vivo evidence for superoxide and peroxide production by adriamycin and cis-platinum. In: Pathology of Oxygen. A. Autor, (Ed.). Academic Press, New York, 1982, pp. 191-202.

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