GSR may refer to:
- Galvanic skin response, a method to understand various types of activity in certain parts of the body
- Gens Sound Record, a sound format for Sega Genesis music
- Glenn Seton Racing, an Australian V8 Supercar motor racing team
- Goshen Scout Reservation, a Boy Scout reservation in Virginia
- Grammata Serica Recensa, a dictionary of Old Chinese by the Swedish sinologist Bernard Karlgren
- Gunshot residue, trace particles left behind by a gun being fired
- SIG Sauer GSR "Granite Series Rail", an M1911-based pistol by SIG Sauer, a Swiss-German weapons manufacturer.
In railways:
- Great Southern Railway (Australia), whose mainline spans the entire continent of Australia, connecting Sydney with Perth
- Great Southern Railway (Western Australia), which connects Beverley and Albany
- Great Southern Railways, which operated all rails within the Irish Free State from 1925 through 1945
GSR may also be used for:
- Cisco 12000 or Gigabit Switch Router, an Internet router made by Cisco Systems
- GSR, a series of bass guitars by Ibanez
- GSR (Ground Surveillance Radar), a military radar used to detect personnel, wheeled and tracked vehicular movement.
- GSR (General Service Representative), an elected service position in Alcoholics Anonymous.
- GSR (Gold/Silver Ratio), the ratio of the cost between Gold and Silver, historically 15:1.