GS may stand for:
In science and technology:
- .gs, the Internet country code top-level domain of South Georgia and the South Sandwich Islands
- Gs, the abbreviated expression for measuring g-force
- GS, a group separator character in the C0 control code set
- GS register in X86 computer architecture
- Roland GS, an extension of General MIDI electronic musical instruments' specification by Roland Corporation
- Glide slope, part of the instrument landing system
- Ground Speed, the speed of an aircraft relative to the ground
- Genome Sequencer, a scientific instrument made by 454 Life Sciences
- Geprüfte Sicherheit, a safety mark appearing on electrical equipment
- Ghostscript, a free software suite for handling PostScript and Portable Document Format (PDF) files
In entertainment:
- Giant Slalom skiing, an alpine skiing discipline often abbreviated GS
- Pokémon Gold and Silver, the second installments of the Pokémon series of role-playing video games
In organizations:
- GS (Swedish union), a trade union in Sweden
- GS Group, a Korean company that is a spin-off from the LG Group
- Goldman Sachs, one of the world's largest global investment banks
- CDM Gold Standard, a Swiss-based non-profit organization that provides additional brand value to Carbon Credits
In automotives:
- BMW GS, a series of dual purpose off-road/on-road BMW motorcycles
- Lexus GS, an executive performance saloon manufactured by TMC division Lexus
- Buick Gran Sport, a high-performance option package available on a number of Buick models
- Citroën GS, a model of car produced by French automobile manufacturer Citroën
- Suzuki GS series, a line of motorcycles
- Chevrolet_Corvette_(C6)#Grand_Sport, a Chevrolet Corvette trim.
- Bugatti Veyron Grand Sport, a Bugatti Veyron trim.
In other:
- GS, the ISO country code of South Georgia and the South Sandwich Islands
- Gs alpha subunit, a subtype of G-protein coupled receptors
- Gilbert's syndrome, a liver enzyme disorder which can cause elevated levels of serum bilirubin
- General Schedule, a prefix designating a pay grade in the United States civil service