Scope
An example of a Grob-like fragmentation in organic synthesis is the expansion of the Wieland-Miescher ketone (1 in scheme 2) to Thapsigargin.
| Scheme 2. Grob-like fragmentation in Thapsigargin synthesis |
|---|
Another example is an epoxy alcohol fragmentation reaction as part of the Holton Taxol total synthesis.
The Grob fragmentation has been applied in the synthesis of the fragrance muscenone (scheme 3)
| Scheme 3. (+)-(R,Z)-5-Muscenone synthesis |
|---|
Read more about this topic: Grob Fragmentation
Famous quotes containing the word scope:
“Every person is responsible for all the good within the scope of his abilities, and for no more, and none can tell whose sphere is the largest.”
—Gail Hamilton (1833–1896)
“A country survives its legislation. That truth should not comfort the conservative nor depress the radical. For it means that public policy can enlarge its scope and increase its audacity, can try big experiments without trembling too much over the result. This nation could enter upon the most radical experiments and could afford to fail in them.”
—Walter Lippmann (1889–1974)
“As the creative adult needs to toy with ideas, the child, to form his ideas, needs toys—and plenty of leisure and scope to play with them as he likes, and not just the way adults think proper. This is why he must be given this freedom for his play to be successful and truly serve him well.”
—Bruno Bettelheim (20th century)