Scope
An example of a Grob-like fragmentation in organic synthesis is the expansion of the Wieland-Miescher ketone (1 in scheme 2) to Thapsigargin.
| Scheme 2. Grob-like fragmentation in Thapsigargin synthesis |
|---|
Another example is an epoxy alcohol fragmentation reaction as part of the Holton Taxol total synthesis.
The Grob fragmentation has been applied in the synthesis of the fragrance muscenone (scheme 3)
| Scheme 3. (+)-(R,Z)-5-Muscenone synthesis |
|---|
Read more about this topic: Grob Fragmentation
Famous quotes containing the word scope:
“Each man must have his “I;” it is more necessary to him than bread; and if he does not find scope for it within the existing institutions he will be likely to make trouble.”
—Charles Horton Cooley (1864–1929)
“As the creative adult needs to toy with ideas, the child, to form his ideas, needs toys—and plenty of leisure and scope to play with them as he likes, and not just the way adults think proper. This is why he must be given this freedom for his play to be successful and truly serve him well.”
—Bruno Bettelheim (20th century)
“The scope of modern government in what it can and ought to accomplish for its people has been widened far beyond the principles laid down by the old “laissez faire” school of political rights, and the widening has met popular approval.”
—William Howard Taft (1857–1930)