Griff may refer to:
- Griff (TV series), a short-lived ABC television series that lasted from 1973-1974
- Griffin, a legendary creature with the body of a lion and the head of an eagle
- Griff Rhys Jones, a British comedian, writer and actor
- Griff Tannen, a fictional character in Back to the Future Part II
- Griff, a fictional character in TV series Married... with Children, portrayed by Harold Sylvester
- Griff, Warwickshire, a place in England
- Nuneaton Griff F.C., a football club
- Griff., the botanical author abbreviation for William Griffith (botanist)
- Grif, one of the characters in Red vs. Blue
- Griff, the armored fans on a dragon's head in E. E. Knight's Age of Fire series
- Professor Griff, an American rapper
- Griff (Rave Master) anime character
- Griff, one of the key London Clan gargoyle allies of the Manhattan Clan in the Disney animated series Gargoyles.
- Griff, Service Desk Manager known also as Geoff or Pan