Grb2

GRB2

Identifiers Symbols GRB2; ASH; EGFRBP-GRB2; Grb3-3; MST084; MSTP084; NCKAP2 External IDs OMIM: 108355 MGI: 95805 HomoloGene: 1576 ChEMBL: 3663 GeneCards: GRB2 Gene

Gene Ontology
Molecular function	• phosphotyrosine binding • SH3/SH2 adaptor activity • epidermal growth factor receptor binding • neurotrophin TRKA receptor binding • protein binding • protein kinase binding • protein phosphatase binding • protein domain specific binding • identical protein binding • insulin receptor substrate binding • ephrin receptor binding
Cellular component	• nucleus • cytoplasm • endosome • Golgi apparatus • cytosol • plasma membrane • signalosome • vesicle membrane • Grb2-EGFR complex
Biological process	• epidermal growth factor receptor signaling pathway • Ras protein signal transduction • cell-cell signaling • axon guidance • aging • blood coagulation • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway • virus-host interaction • platelet activation • positive regulation of actin filament polymerization • T cell costimulation • receptor internalization • negative regulation of epidermal growth factor receptor signaling pathway • signal transduction in response to DNA damage • regulation of MAPK cascade • nerve growth factor receptor signaling pathway • leukocyte migration • protein heterooligomerization • branching involved in labyrinthine layer morphogenesis • cellular response to ionizing radiation • positive regulation of reactive oxygen species metabolic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 2885 14784 Ensembl ENSG00000177885 ENSMUSG00000059923 UniProt P62993 Q60631 RefSeq (mRNA) NM_002086.4 NM_008163.3 RefSeq (protein) NP_002077.1 NP_032189.1 Location (UCSC) Chr 17:
73.31 – 73.4 Mb Chr 11:
115.64 – 115.71 Mb PubMed search

Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene.