GRB2

GRB2

Identifiers Symbols GRB2; ASH; EGFRBP-GRB2; Grb3-3; MST084; MSTP084; NCKAP2 External IDs OMIM: 108355 MGI: 95805 HomoloGene: 1576 ChEMBL: 3663 GeneCards: GRB2 Gene

Gene Ontology
Molecular function	• phosphotyrosine binding • SH3/SH2 adaptor activity • epidermal growth factor receptor binding • neurotrophin TRKA receptor binding • protein binding • protein kinase binding • protein phosphatase binding • protein domain specific binding • identical protein binding • insulin receptor substrate binding • ephrin receptor binding
Cellular component	• nucleus • cytoplasm • endosome • Golgi apparatus • cytosol • plasma membrane • signalosome • vesicle membrane • Grb2-EGFR complex
Biological process	• epidermal growth factor receptor signaling pathway • Ras protein signal transduction • cell-cell signaling • axon guidance • aging • blood coagulation • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway • virus-host interaction • platelet activation • positive regulation of actin filament polymerization • T cell costimulation • receptor internalization • negative regulation of epidermal growth factor receptor signaling pathway • signal transduction in response to DNA damage • regulation of MAPK cascade • nerve growth factor receptor signaling pathway • leukocyte migration • protein heterooligomerization • branching involved in labyrinthine layer morphogenesis • cellular response to ionizing radiation • positive regulation of reactive oxygen species metabolic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 2885 14784 Ensembl ENSG00000177885 ENSMUSG00000059923 UniProt P62993 Q60631 RefSeq (mRNA) NM_002086.4 NM_008163.3 RefSeq (protein) NP_002077.1 NP_032189.1 Location (UCSC) Chr 17:
73.31 – 73.4 Mb Chr 11:
115.64 – 115.71 Mb PubMed search

Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene.

The protein encoded by this gene binds receptors such as the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the sem-5 gene of Caenorhabditis elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.