Gn RH Agonists - Agonists With Double and Single Substitutions

Agonists With Double and Single Substitutions

GnRH agonists are synthetically modeled after the natural GnRH decapeptide with specific amino acid substitutions typically in position 6 and 10. These substitutions inhibit rapid degradation. Agonists with 2 substitutions include:

  1. leuprolide (Lupron, Eligard)
  2. buserelin (Suprefact, Suprecor)
  3. nafarelin (Synarel) (only a single substitution at position 6)
  4. histrelin (Supprelin LA, Vantas)
  5. goserelin (Zoladex)
  6. deslorelin (Suprelorin, Ovuplant)

Triptorelin is an agonist with only a single substitution at position 6.

  • Leuprolide

  • Buserelin

  • Nafarelin

  • Histrelin

  • Goserelin

  • Deslorelin

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