Measuring A1C
There are a number of techniques used to measure A1C.
Laboratories use:
- high-performance liquid chromatography (HPLC): The HbA1c result is calculated as a ratio to total hemoglobin by using a chromatogram.
- immunoassay
- Enzymatic
- Capillary Electrophoresis
Point of care (e.g., doctor's surgery) devices use:
- immunoassay
- boronate affinity chromatography
In the United States, A1C testing laboratories are certified by the National Glycohemoglobin Standardization Program (NGSP) to standardise them against the results of the 1993 Diabetes Control and Complications Trial (DCCT). There is an additional percentage scale, Mono S, that is in use by Japan and Sweden.
Read more about this topic: Glycated Hemoglobin
Famous quotes containing the word measuring:
“As an example of just how useless these philosophers are for any practice in life there is Socrates himself, the one and only wise man, according to the Delphic Oracle. Whenever he tried to do anything in public he had to break off amid general laughter. While he was philosophizing about clouds and ideas, measuring a flea’s foot and marveling at a midge’s humming, he learned nothing about the affairs of ordinary life.”
—Desiderius Erasmus (c. 1466–1536)